Preferred Name |
pancreas |
Definitions |
产生消化酶前体和血糖调节酶的内胚层衍生结构[GO]。 An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. |
ID |
http://purl.obolibrary.org/obo/UBERON_0001264 |
depicted_by |
https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png |
function_notes |
The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans 高等脊椎动物和哺乳动物的成熟胰腺包括两个主要功能单元:负责分泌到肠腔中的消化酶的分泌的外分泌胰腺和在食物摄取和代谢中具有关键调节功能的几种激素的合成中起作用的内分泌胰腺。外分泌部分构成胰腺肿块的大部分,仅含有两种不同类型的细胞,即分泌腺泡细胞和小管细胞。仅占总质量的1-2%的内分泌部分包含五种不同的细胞类型,其被组织成称为胰岛的混合功能组件。 |
hasDbXref |
ZFA:0000140 EV:0100092 UMLS:C0030274 TAO:0000140 BTO:0000988 CALOHA:TS-0736 MESH:D010179 EHDAA:6893 OpenCyc:Mx4rvVimZZwpEbGdrcN5Y29ycA XAO:0000136 EMAPA:17503 galen:Pancreas AAO:0010112 MIAA:0000075 FMA:7198 MA:0000120 EFO:0000855 MAT:0000075 EHDAA2:0001367 VHOG:0000050 GAID:334 http://linkedlifedata.com/resource/umls/id/C0030274 http://en.wikipedia.org/wiki/Pancreas |
hasOBONamespace |
uberon |
id |
UBERON:0001264 |
inSubset |
http://purl.obolibrary.org/obo/uberon/core#major_organ http://purl.obolibrary.org/obo/uberon/core#uberon_slim http://purl.obolibrary.org/obo/uberon/core#organ_slim http://purl.obolibrary.org/obo/uberon/core#pheno_slim |
label |
pancreas 胰腺 |
prefixIRI |
UBERON:0001264 |
prefLabel |
pancreas |
textual definition |
产生消化酶前体和血糖调节酶的内胚层衍生结构[GO]。 An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. |
分类_注释 |
胰腺作为一种分泌器官,具有外分泌和内分泌的功能,对脊椎动物有特异性;[PMID:16417468] 石斑鱼和文昌鱼在其内分泌胰腺(胰岛或胰)和外分泌胰腺的完全分离方面是独特的(50)。内分泌胰腺和外分泌胰腺在齿科中共存(50)。在文昌鱼和海鞘中,没有像石斑鱼、栉孔扇贝和海鞘中那样的憩室,只有分散在胃肠道壁中的胰岛素分泌细胞(51,52)。 斑马鱼没有离散的胰腺。外分泌胰腺组织可沿肠道散布。外分泌胰腺的腺泡结构与哺乳动物非常相似,并且包含具有非常黑暗的嗜碱性细胞质的细胞 The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract. The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52) |
同源_注释 |
在河豚鱼和七鳃鳗(今天我们最原始的脊椎动物物种)中,发现了"新器官丛"的第一个标志,它是胆管与十二指肠连接区域周围的内分泌细胞的集合。这些内分泌器官由99%β 细胞和1%生长抑素产生的δ细胞组成。与更原始的原脊索(例如文昌鱼)相比,这代表了肠组织的所有先前分散的胰岛素产生细胞现在已经定量迁移以发现参与感测血糖而不是肠葡萄糖的新器官的阶段。在进化的后期,β 细胞与外分泌组织和 α 细胞结合(以大鼠、兔和象鱼为例)。最后,从鲨鱼的角度出发,从进化的角度出发,使胰岛PP细胞进入胰腺,完成胰腺的发育。[well established][VHOG] In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] |
外部_定义 |
Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO] 分泌液体的器官,液体中含有有助于食物消化的酶。[AAO] |
引自 |
http://purl.obolibrary.org/obo/uberon.owl |
有_关系_形容词 |
胰 pancreatic |
subClassOf | |
has_part |