Alzheimer's Disease Pathway KEGG

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38778

Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.

C38778

Alzheimer's Disease

Alzheimer's Disease Pathway KEGG

hsa05010

Alzheimer's Disease Pathway KEGG

Alzheimers_Disease_Pathway

Alzheimer's Disease Pathway KEGG

Thesaurus:C38778

Alzheimer's Disease Pathway KEGG

Functional Concept

C1521724

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39737