loading...| Preferred Name |
Prion Pathway |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39201 |
| ALT_DEFINITION |
Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded oligomeric form, PrP(Sc). PrP is a cell membrane GPI anchored glycoprotein that is expressed in most tissues and in high levels in the nervous system. Some likely cellular functions of PrP are (1) cell protection against oxidative stress, (2) induction of neuronal cell adhesion, neurite extension and maintenance, and (3) neuroprotective signaling through a cAMP/PKA-dependent pathway. (This definition may be outdated - see the DesignNote.) |
| BioCarta_ID |
h_prionPathway |
| code |
C39201 |
| DesignNote |
The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/. |
| FULL_SYN |
Prion Pathway |
| label |
Prion Pathway |
| Legacy Concept Name |
Prion_Pathway |
| Preferred_Name |
Prion Pathway |
| prefixIRI |
Thesaurus:C39201 |
| prefLabel |
Prion Pathway |
| Semantic_Type |
Functional Concept |
| UMLS_CUI |
C1514452 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||