loading...| Preferred Name |
Type II Diabetes Mellitus Pathway |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91490 |
| ALT_DEFINITION |
Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process. |
| code |
C91490 |
| FULL_SYN |
Type II Diabetes Mellitus Pathway Type II diabetes mellitus |
| KEGG_ID |
hsa04930 |
| label |
Type II Diabetes Mellitus Pathway |
| Preferred_Name |
Type II Diabetes Mellitus Pathway |
| prefixIRI |
Thesaurus:C91490 |
| prefLabel |
Type II Diabetes Mellitus Pathway |
| Semantic_Type |
Functional Concept |
| UMLS_CUI |
C2984301 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||