Preferred Name

Type I Diabetes Mellitus Pathway

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91529

ALT_DEFINITION

Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).

code

C91529

FULL_SYN

Type I Diabetes Mellitus Pathway

Type I diabetes mellitus

KEGG_ID

hsa04940

label

Type I Diabetes Mellitus Pathway

Preferred_Name

Type I Diabetes Mellitus Pathway

prefixIRI

Thesaurus:C91529

prefLabel

Type I Diabetes Mellitus Pathway

Semantic_Type

Functional Concept

UMLS_CUI

C2984334

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39701

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