Preferred Name |
Type I Diabetes Mellitus Pathway |
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91529 |
ALT_DEFINITION |
Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma). |
code |
C91529 |
FULL_SYN |
Type I Diabetes Mellitus Pathway Type I diabetes mellitus |
KEGG_ID |
hsa04940 |
label |
Type I Diabetes Mellitus Pathway |
Preferred_Name |
Type I Diabetes Mellitus Pathway |
prefixIRI |
Thesaurus:C91529 |
prefLabel |
Type I Diabetes Mellitus Pathway |
Semantic_Type |
Functional Concept |
UMLS_CUI |
C2984334 |
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
There are currently no mappings for this class. |