Preferred Name

esophagus

Synonyms

gullet

oesophagus

Definitions

Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).

ID

http://purl.obolibrary.org/obo/UBERON_0001043

database_cross_reference

OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA

EV:0100069

GAID:291

XAO:0000127

MESH:D004947

BTO:0000959

EMAPA:16833

UMLS:C0014876

ANISEED:1235301

CALOHA:TS-0700

NCIT:C12389

TAO:0000204

MIAA:0000048

EFO:0000835

ZFA:0000204

EHDAA2:0001285

EHDAA:2937

AAO:0000145

VHOG:0000450

FMA:7131

MA:0000352

galen:Esophagus

MAT:0000048

http://linkedlifedata.com/resource/umls/id/C0014876

http://en.wikipedia.org/wiki/Esophagus

http://www.snomedbrowser.com/Codes/Details/181245004

definition

Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).

depicted by

http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg

develops_from

http://purl.obolibrary.org/obo/UBERON_0001041

external_definition

Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]

external_ontology_notes

esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)

has_exact_synonym

gullet

oesophagus

has_obo_namespace

uberon

has_relational_adjective

esophageal

homology_notes

The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]

id

UBERON:0001043

in_subset

http://purl.obolibrary.org/obo/uberon/core#major_organ

http://purl.obolibrary.org/obo/uberon/core#uberon_slim

http://purl.obolibrary.org/obo/uberon/core#organ_slim

http://purl.obolibrary.org/obo/uberon/core#pheno_slim

http://purl.obolibrary.org/obo/uberon/core#efo_slim

http://purl.obolibrary.org/obo/uberon/core#vertebrate_core

label

esophagus

located in

http://purl.obolibrary.org/obo/UBERON_0002224

notation

UBERON:0001043

part_of

http://purl.obolibrary.org/obo/UBERON_0004908

http://purl.obolibrary.org/obo/RO_0002577

prefLabel

esophagus

proximally connected to

http://purl.obolibrary.org/obo/UBERON_0001042

treeView

http://purl.obolibrary.org/obo/UBERON_0001041

http://purl.obolibrary.org/obo/UBERON_0004908

http://purl.obolibrary.org/obo/RO_0002577

subClassOf

http://purl.obolibrary.org/obo/UBERON_0004921

http://purl.obolibrary.org/obo/UBERON_0000062

http://purl.obolibrary.org/obo/UBERON_0005178

http://purl.obolibrary.org/obo/UBERON_0013765

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http://purl.bioontology.org/ontology/LNC/MTHU011962 Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码 LOOM
http://purl.obolibrary.org/obo/BTO_0000959 BRENDA Tissue and Enzyme Source Ontology / 布兰达组织和酶源本体 LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 中国人类表型本体 / Human Phenotype Ontology China LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 中国人类表型本体 / Human Phenotype Ontology China SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 Experimental Factor Ontology / 实验性因素本体 LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 Experimental Factor Ontology / 实验性因素本体 SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 Phenotypic Quality Ontology / 表型特质本体 LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 Phenotypic Quality Ontology / 表型特质本体 SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 Cell Ontology / 细胞本体 LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 Cell Ontology / 细胞本体 SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 International Classification of Diseases Ontology / 国际疾病分类本体 LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 International Classification of Diseases Ontology / 国际疾病分类本体 SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 GenEpiO / 基因组流行病学本体 LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 GenEpiO / 基因组流行病学本体 SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 Cell Line Ontology Subset for Chinese National Infrastructure of 国家实验细胞资源共享服务平台(NICR)细胞系本体子集 / Cell Line Resource (NICR) LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 Cell Line Ontology Subset for Chinese National Infrastructure of 国家实验细胞资源共享服务平台(NICR)细胞系本体子集 / Cell Line Resource (NICR) SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 Human Disease Ontology / 人类疾病本体 LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 Human Disease Ontology / 人类疾病本体 SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 细胞系本体(中文翻译) / Cell Line Ontology (Chinese Translation) SAME_URI
http://purl.obolibrary.org/obo/UBERON_0001043 Ontology for Biobanking / 生物样本库本体 LOOM
http://purl.obolibrary.org/obo/UBERON_0001043 Ontology for Biobanking / 生物样本库本体 SAME_URI
http://purl.bioontology.org/ontology/MESH/D004947 Medical Subject Headings / 医学主题词表 LOOM
http://purl.bioontology.org/ontology/LNC/LP199925-1 Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码 LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12389 National Cancer Institute Thesaurus / 美国国家癌症研究所词典 LOOM
http://purl.bioontology.org/ontology/LNC/LP29941-9 Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码 LOOM
http://purl.org/sig/ont/fma/fma7131 Foundational Model of Anatomy / 解剖学基础模型本体 LOOM
http://purl.bioontology.org/ontology/LNC/LA4018-3 Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码 LOOM
http://purl.bioontology.org/ontology/LNC/LP212082-4 Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码 LOOM