loading...| Preferred Name |
Leukotriene D4 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C180700 |
| CAS_Registry |
73836-78-9 |
| CHEBI_ID |
CHEBI:28666 |
| Chemical_Formula |
C25H40N2O6S |
| code |
C180700 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
A leukotriene synthesized from leukotriene C4 secreted by basophils via removal of a glutamic acid group by cell surface proteases. Leukotriene D4 (LTD4) induces the contraction of smooth muscle cells, which results in bronchoconstriction and vasoconstriction, and increases vascular permeability. LTD4 can be further cleaved by cell surface proteases that remove a glycine group to form leukotriene E4. |
| Display_Name |
Leukotriene D4 |
| FDA_UNII_Code |
5FNY4416UE |
| FULL_SYN |
Glycine, N-(S-(1-(4-Carboxy-1-Hydroxybutyl)-2,4,6,9-Pentadecatetraenyl)-L-Cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))- S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-Hydroxybutyl]Pentadeca-2,4,6,9-Tetraen-1-Yl}-L-Cysteinylglycine (5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-Amino-3-[(Carboxymethyl)Amino]-3-Oxopropyl}Sulfanyl)-5-Hydroxyicosa-7,9,11,14-Tetraenoic Acid LTD4 (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-Hydroxybutyl)-2,4,6,9-Pentadecatetraenyl)-L-Cysteinyl)Glycine LEUKOTRIENE D4 Leukotriene D4 5S-Hydroxy-6R-(S-Cysteinylglycinyl)-7E,9E,11E,14Z-Eicosatetraenoic Acid |
| label |
Leukotriene D4 |
| NCI_META_CUI |
CL1663316 |
| Preferred_Name |
Leukotriene D4 |
| prefixIRI |
Thesaurus:C180700 |
| prefLabel |
Leukotriene D4 |
| Semantic_Type |
Biologically Active Substance Organic Chemical |
| subClassOf |