B Cell Receptor Signaling Pathway

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91456

B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.

C91456

B cell receptor signaling pathway

B Cell Receptor Signaling Pathway

BCR Signaling Pathway

hsa04662

B Cell Receptor Signaling Pathway

CL422162

B Cell Receptor Signaling Pathway

Thesaurus:C91456

B Cell Receptor Signaling Pathway

Functional Concept

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39698