Preferred Name

Dilated Cardiomyopathy Pathway

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91470

ALT_DEFINITION

Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia. Genetically inherited forms of DCM ("familial" DCM) have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of "familial" DCM. The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission. In cases where an underlying pathology cannot be identified, the patient is diagnosed with an "idiopathic" DCM. Current hypotheses regarding causes of "idiopathic" DCM focus on chronic viral myocarditis and/or on autoimmune abnormalities. Viral myocarditis may progress to an autoimmune phase and then to progressive cardiac dilatation. Antibodies to the beta1-adrenergic receptor (beta1AR), which are detected in a substantial number of patients with "idiopathic" DCM, may increase the concentration of intracellular cAMP and intracellular Ca2+, a condition often leading to a transient hyper-performance of the heart followed by depressed heart function and heart failure.

code

C91470

FULL_SYN

Dilated Cardiomyopathy Pathway

DCM Pathway

Dilated cardiomyopathy

KEGG_ID

hsa05414

label

Dilated Cardiomyopathy Pathway

Preferred_Name

Dilated Cardiomyopathy Pathway

prefixIRI

Thesaurus:C91470

prefLabel

Dilated Cardiomyopathy Pathway

Semantic_Type

Functional Concept

UMLS_CUI

C2984282

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39701

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http://purl.obolibrary.org/obo/PW_0001036 Pathway Ontology / 通路本体 LOOM