loading...| Preferred Name |
IkappaB kinase complex |
| Synonyms |
heterotrimeric IKK complex |
| Definitions |
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| ID |
http://purl.obolibrary.org/obo/GO_0008385 |
| definition |
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| has_exact_synonym |
heterotrimeric IKK complex |
| has_obo_namespace |
cellular_component |
| id |
GO:0008385 |
| label |
IkappaB kinase complex |
| notation |
GO:0008385 |
| prefLabel |
IkappaB kinase complex |
| treeView | |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/GO_0008385 | Gene Ontology / 基因本体 | LOOM | |
| http://purl.obolibrary.org/obo/GO_0008385 | Gene Ontology / 基因本体 | SAME_URI |