Preferred Name |
GAIT complex |
Synonyms |
gamma interferon-activated inhibitor of translation complex |
Definitions |
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. |
ID |
http://purl.obolibrary.org/obo/GO_0097452 |
definition |
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. |
has_exact_synonym |
gamma interferon-activated inhibitor of translation complex |
has_obo_namespace |
cellular_component |
id |
GO:0097452 |
label |
GAIT complex |
notation |
GO:0097452 |
prefLabel |
GAIT complex |
treeView | |
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.obolibrary.org/obo/GO_0097452 | Gene Ontology / 基因本体 | LOOM | |
http://purl.obolibrary.org/obo/GO_0097452 | Gene Ontology / 基因本体 | SAME_URI |