Preferred Name

GAIT complex

Synonyms

gamma interferon-activated inhibitor of translation complex

Definitions

A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.

ID

http://purl.obolibrary.org/obo/GO_0097452

definition

A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.

has_exact_synonym

gamma interferon-activated inhibitor of translation complex

has_obo_namespace

cellular_component

id

GO:0097452

label

GAIT complex

notation

GO:0097452

prefLabel

GAIT complex

treeView

http://purl.obolibrary.org/obo/GO_0032991

subClassOf

http://purl.obolibrary.org/obo/GO_0032991

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http://purl.obolibrary.org/obo/GO_0097452 Gene Ontology / 基因本体 LOOM
http://purl.obolibrary.org/obo/GO_0097452 Gene Ontology / 基因本体 SAME_URI