loading...| Preferred Name |
Acute megakaryoblastic leukemia |
| ID |
http://www.orpha.net/ORDO/Orphanet_518 |
| alternative_term |
AML M7 Acute myeloid leukemia M7 AMKL Acute megakaryocytic leukemia |
| definition |
A rare acute myeloid leukemia that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis. |
| definition_citation |
Orphanet |
| expertlink |
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=518 |
| has_age_of_onset |
Childhood |
| has_inheritance |
Not applicable |
| hasDbXref |
UMLS:C0023462 ICD-11:2A60.36 ICD-10:C94.2 |
| label |
Acute megakaryoblastic leukemia |
| notation |
ORPHA:518 |
| part_of | |
| prefixIRI |
ORDO:Orphanet_518 |
| prefLabel |
Acute megakaryoblastic leukemia |
| present_in |
Europe AND has_point_prevalence_range : <1 / 1 000 000 Europe AND has_annual_incidence_average_value : 0.02 AND has_annual_incidence_range : <1 / 1 000 000 |
| treeView | |
| subClassOf |