loading...| Preferred Name |
Hypoxanthine Phosphoribosyltransferase |
| Synonyms |
IMP:pyrophosphate phospho-D-ribosyltransferase |
| Definitions |
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8. |
| ID |
http://purl.bioontology.org/ontology/MESH/D007041 |
| altLabel |
IMP:pyrophosphate phospho-D-ribosyltransferase Phosphoribosyltransferase, Hypoxanthine Hypoxanthine Guanine Phosphoribosyltransferase IMP Pyrophosphorylase Guanine Phosphoribosyltransferase HPRT HPRTase Phosphoribosyltransferase, Guanine Pyrophosphorylase, IMP HGPRT Phosphoribosyltransferase, Hypoxanthine-Guanine Hypoxanthine-Guanine Phosphoribosyltransferase |
| AN |
/defic: consider also LESCH-NYHAN SYNDROME or GOUT |
| AQL |
AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
| cui |
C0020687 |
| DC |
1 |
| definition |
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8. |
| DX |
19750901 |
| FX |
D006073 D007926 |
| HN |
75; GUANINE PHOSPHORIBOSYLTRANSFERASE was GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1978-91 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000172 |
| Inverse of RB |
EC 2.4.2.8 |
| Inverse of RO | |
| Machine permutation |
75; GUANINE PHOSPHORIBOSYLTRANSFERASE was indexed under PENTOSYLTRANSFERASES 1978-91 |
| Mapped from | |
| MDA |
19741111 |
| MMR |
20190524 |
| MN |
D08.811.913.400.725.450 |
| notation |
D007041 |
| OL |
use HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE (NM) to search GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1980-91 |
| prefLabel |
Hypoxanthine Phosphoribosyltransferase |
| RR |
9016-12-0 (CAS RN) |
| TERMUI |
T021074 T021077 T021078 T021076 T021080 T021075 T021079 |
| TH |
NLM (1975) NLM (1998) UNK (19XX) NLM (1992) NLM (1994) |
| tui |
T116 T126 |
| subClassOf |