loading...| Preferred Name |
Renin-Angiotensin System |
| Synonyms |
System, Renin-Angiotensin |
| Definitions |
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM. |
| ID |
http://purl.bioontology.org/ontology/MESH/D012084 |
| altLabel |
System, Renin-Angiotensin Renin Angiotensin System Renin-Angiotensin-Aldosterone System System, Renin-Angiotensin-Aldosterone Renin Angiotensin Aldosterone System |
| AN |
note entry term but do not index under ALDOSTERONE unless particularly discussed |
| AQL |
DE GE IM PH RE |
| cui |
C0086907 C0035096 |
| DC |
1 |
| definition |
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM. |
| DX |
19820101 |
| FX |
D016234 D000806 |
| HN |
82 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000235 |
| Inverse of RO |
http://purl.bioontology.org/ontology/MESH/D016234 http://purl.bioontology.org/ontology/MESH/D000450 http://purl.bioontology.org/ontology/MESH/D000804 |
| Machine permutation |
82 |
| MDA |
19810519 |
| MMR |
20160701 |
| MN |
G09.330.380.813 G03.820 |
| notation |
D012084 |
| prefLabel |
Renin-Angiotensin System |
| TERMUI |
T035940 T035939 |
| TH |
NLM (1982) UNK (19XX) |
| tui |
T022 |
| subClassOf |