An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui
C0035179
C1564034
C0729166
C0729164
C1564035
C0729165
C0729168
DC
1
definition
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
DX
19600101
HN
RESERPINE DERIVATIVES was see under RESERPINE 1975-77, was see under YOHIMBANS 1969-74; /adv eff-pois-tox was RESERPINE TOXICOLOGY 1963-65
RESERPINE DERIVATIVES was see under RESERPINE 1975-77, was see under YOHIMBANS 1969-74; /adverse effects /poisoning /toxicity were RESERPINE TOXICOLOGY 1963-65
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