loading...| Preferred Name |
Trimetrexate |
| Synonyms |
CI 898 |
| Definitions |
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect. |
| ID |
http://purl.bioontology.org/ontology/MESH/D016597 |
| altLabel |
CI 898 NSC 328564 Trimetrexate Hydrate Monohydrate, Monoacetate Trimetrexate Hydrate, Trimetrexate 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)- NSC-328564 NSC249008 CI898 NSC-249008 JB-11 JB 11 Trimetrexate Monohydrate, Monoacetate JB11 CI-898 NSC 249008 NSC328564 |
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
| cui |
C0887709 C0701240 C0701241 C0701242 C0887710 C0085176 C0701239 |
| DC |
1 |
| definition |
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect. |
| DX |
19920101 |
| HN |
92; was TRIMETREXATE (NM) 1979-91 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 |
| Inverse of RB |
117381-10-9 UPN4ITI8T4 0 117381-09-6 |
| isa |
http://purl.bioontology.org/ontology/MESH/D000935 |
| Machine permutation |
92; TRIMETREXATE was indexed under QUINAZOLINES 1979-91 |
| Mapped from | |
| MDA |
19910125 |
| MMR |
20170524 |
| MN |
D03.633.100.786.925 |
| notation |
D016597 |
| OL |
use TRIMETREXATE (NM) to search TRIMETREXATE 1980-91 |
| PA |
D005493 D000935 D000964 |
| prefLabel |
Trimetrexate |
| RR |
117381-09-6 (monohydrate, monoacetate) 52128-35-5 (Trimetrexate) 117381-10-9 (hydrate) |
| TERMUI |
T361489 T049710 T049712 T361490 T049709 T049708 T049711 |
| TH |
FDA SRS (2014) NLM (1992) USAN (1981) NLM (1999) INN (19XX) |
| tui |
T109 T121 |
| subClassOf |