loading...| Preferred Name |
11-beta-Hydroxysteroid Dehydrogenase Type 2 |
| Synonyms |
11beta-HSD2 Reductase |
| Definitions |
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME. |
| ID |
http://purl.bioontology.org/ontology/MESH/D043209 |
| altLabel |
11beta-HSD2 Reductase 11beta-Hydroxysteroid Dehydrogenase Type 2 11beta-HSD2 11 beta Hydroxysteroid Dehydrogenase Type 2 11 beta-HSD2 11beta Hydroxysteroid Dehydrogenase Type 2 11 beta-Hydroxysteroid Dehydrogenase Type 2 |
| AQL |
AD AE AI AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
| cui |
C0608861 |
| DC |
1 |
| definition |
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME. |
| DX |
20040101 |
| EC |
deficiency:Mineralocorticoid Excess Syndrome, Apparent |
| HN |
2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 |
| Inverse of RB |
EC 1.1.1.146 |
| Machine permutation |
2004; 11 BETA-HSD2 was indexed under HYDROXYSTEROID DEHYDROGENASES 1992-2003 |
| Mapped from | |
| MDA |
20030709 |
| MMR |
20130708 |
| MN |
D08.811.682.047.820.100.600 D08.811.682.047.436.174.600 |
| notation |
D043209 |
| prefLabel |
11-beta-Hydroxysteroid Dehydrogenase Type 2 |
| TERMUI |
T106302 T405109 T542236 T526968 T526969 T405110 |
| TH |
NLM (2004) |
| tui |
T116 T126 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/PR_000008772 | Protein Ontology / 蛋白质本体 | LOOM |