Preferred Name |
cyclin-dependent protein kinase activating kinase holoenzyme complex |
Synonyms |
CAK complex |
Definitions |
A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. |
ID |
http://purl.obolibrary.org/obo/GO_0019907 |
definition |
A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. |
has_exact_synonym |
CAK complex |
has_obo_namespace |
cellular_component |
id |
GO:0019907 |
label |
cyclin-dependent protein kinase activating kinase holoenzyme complex |
notation |
GO:0019907 |
prefLabel |
cyclin-dependent protein kinase activating kinase holoenzyme complex |
treeView | |
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.obolibrary.org/obo/GO_0019907 | Gene Ontology / 基因本体 | LOOM | |
http://purl.obolibrary.org/obo/GO_0019907 | Gene Ontology / 基因本体 | SAME_URI |