Preferred Name |
death-inducing signaling complex |
Synonyms |
death receptor-induced signaling complex |
Definitions |
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. |
ID |
http://purl.obolibrary.org/obo/GO_0031264 |
comment |
Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. |
definition |
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. |
has_exact_synonym |
death receptor-induced signaling complex |
has_obo_namespace |
cellular_component |
id |
GO:0031264 |
label |
death-inducing signaling complex |
notation |
GO:0031264 |
prefLabel |
death-inducing signaling complex |
treeView | |
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.obolibrary.org/obo/GO_0031264 | Gene Ontology / 基因本体 | LOOM | |
http://purl.obolibrary.org/obo/GO_0031264 | Gene Ontology / 基因本体 | SAME_URI |