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Median life expectancy 13 years (in most patients) [MISCELLANEOUS] Majority of classic cases have a single de novo mutation (GLY608GLY, 150330.0022) [MISCELLANEOUS] Somatic mosaicism and apparent germline mosaicism have been reported [MISCELLANEOUS] Some patients have an atypical phenotype with a later age at diagnosis and more protracted disease course [MISCELLANEOUS] Median age of clinical diagnosis 19 months (in most patients) [MISCELLANEOUS] Caused by mutation in the lamin A/C gene (LMNA, 150330.0022) [MOLECULAR BASIS] Paternal age effect [MISCELLANEOUS] Premature aging [MISCELLANEOUS]
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