loading...| Preferred Name |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO |
| Synonyms |
Alpha Ketoglutarate Dependent Dioxygenase |
| Definitions |
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS. |
| ID |
http://purl.bioontology.org/ontology/MESH/D000071516 |
| altLabel |
Alpha Ketoglutarate Dependent Dioxygenase Fat Mass and Obesity Associated Protein Alpha Ketoglutarate Dependent Dioxygenase FTO Fat Mass and Obesity Associated (FTO) Protein Dioxygenase, Alpha-Ketoglutarate-Dependent AlkB Homolog 9 Protein Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Alpha-Ketoglutarate-Dependent Dioxygenase |
| AQL |
AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
| cui |
C4255071 |
| DC |
1 |
| definition |
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS. |
| DX |
20170101 |
| HN |
2017 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000172 |
| Inverse of RB |
EC 1.14.11.33 |
| Machine permutation |
2017 |
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C529321 |
| MDA |
20160708 |
| MMR |
20160628 |
| MN |
D08.811.074.062.968 D08.811.682.690.416.139.992 D08.811.682.662.582.242 |
| notation |
D000071516 |
| prefLabel |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO |
| TERMUI |
T000895767 T000895768 T000895780 T000898936 T000895769 |
| TH |
NLM (2017) |
| tui |
T116 T126 |
| subClassOf |