loading...| Preferred Name |
Thyroxine |
| Synonyms |
3,5,3',5'-Tetraiodothyronine |
| Definitions |
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism. |
| ID |
http://purl.bioontology.org/ontology/MESH/D013974 |
| altLabel |
3,5,3',5'-Tetraiodothyronine Thyroid Hormone, T4 L-Thyroxin Henning T4 Thyroid Hormone O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine Levo-T Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo- L-Thyroxine Roche Tiroidine L-3,5,3',5'-Tetraiodothyronine Levothroid Levoxyl Berlthyrox Synthrox L Thyroxin beta Eltroxin Novothyrox L-Thyrox Dexnon Novothyral L-Thyroxin beta Eutirox Levothyroid Eferox Oroxine L Thyrox Levo T O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine Tiroxina Leo Levothyroxine Synthroid Sodium Levothyroxine Levothyroxine Sodium Levothyroxin Delalande Levothyroxin Deladande L Thyroxin Henning Levoxine Eltroxine Lévothyrox L Thyroxine Roche Thyrax L Thyroxine Thevier Euthyrox L-Thyroxine Unithroid Thyroxin |
| AN |
/blood: consider also HYPERTHYROXINEMIA |
| AQL |
AA AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR |
| cui |
C1450022 C1450017 C0079691 C1450018 C1881373 C0721345 C1450012 C1450019 C1450014 C0721340 C0939521 C1450015 C0728762 C0733607 C1450021 C0040165 C0720313 C1450024 C1450023 C0733849 C0591440 C1450011 C0733848 C0721346 C0733850 C1450020 C1450013 C1450016 C1450025 |
| DC |
1 |
| definition |
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism. |
| DX |
19650101 |
| FX |
D011988 D006981 |
| HN |
1965; use THYROXIN 1963-1964; for LEVOTHYROXINE use LEVOTHYROXINE 1991-2001, use THYROXINE 1966-1990 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000172 |
| Inverse of RB |
0 Q51BO43MG4 |
| Inverse of RO | |
| LT |
TRD |
| Machine permutation |
1965; see THYROXIN 1963-1964; for LEVOTHYROXINE see LEVOTHYROXINE 1991-2001, see THYROXINE 1966-1990, see LEVOTHYROXINE 1963-1965 |
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C018591 http://purl.bioontology.org/ontology/MESH/C011126 http://purl.bioontology.org/ontology/MESH/C018539 http://purl.bioontology.org/ontology/MESH/C054785 http://purl.bioontology.org/ontology/MESH/C010150 http://purl.bioontology.org/ontology/MESH/C000626766 http://purl.bioontology.org/ontology/MESH/C414394 http://purl.bioontology.org/ontology/MESH/C015042 http://purl.bioontology.org/ontology/MESH/C010516 |
| MDA |
19990101 |
| MMR |
20180228 |
| MN |
D12.125.072.050.767 D06.472.931.812 |
| notation |
D013974 |
| prefLabel |
Thyroxine |
| RR |
7488-70-2 (Thyroxine) 51-48-9 |
| TERMUI |
T580452 T580506 T048346 T580504 T100176 T580467 T580470 T048347 T048345 T580491 T580478 T048349 T580497 T580456 T040986 T048353 T580513 T048354 T040987 T580493 T048352 T040985 T580509 T580468 T580495 T580485 T580511 T048348 T580454 T580472 T580458 T580475 T436487 T580462 T048350 T048351 T040984 T580482 T580480 T040988 |
| TH |
FDA SRS (2014) NLM (1991) US NL IE NLM (1965) UNK (19XX) DE NLM (2002) NLM (1996) CA AU MX FR NLM (2005) UK ES |
| tui |
T125 T109 T116 T121 |
| subClassOf |