loading...| Preferred Name |
microglial cell |
| Synonyms |
microgliocyte MF.microglia.CNS brain-resident macrophage microglia hortega cells brain macrophage |
| Definitions |
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. |
| ID |
http://purl.obolibrary.org/obo/CL_0000129 |
| comment |
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. |
| capable of | |
| database_cross_reference |
FMA:54539 FMA:54540 BTO:0000078 BTO:0000962 |
| definition |
A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. |
| develops_from | |
| has plasma membrane part |
http://purl.obolibrary.org/obo/PR_000001012 |
| has_broad_synonym |
brain macrophage |
| has_exact_synonym |
microgliocyte brain-resident macrophage hortega cells |
| has_related_synonym |
MF.microglia.CNS microglia |
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
| label |
microglial cell |
| prefixIRI |
CL:0000129 |
| prefLabel |
microglial cell |
| present_in_taxon | |
| treeView | |
| subClassOf |
http://purl.obolibrary.org/obo/CL_0000125 |