T-Cell Receptor

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17065

C17065

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

CTRP

Heterodimeric antigen receptors present on the surface of T-cells. Two T-cell antigen receptors have been identified, consisting of heterodimeric 40-55 kD Ig-like alpha/beta or gamma/delta integral membrane glycoproteins. Genes for TCR alpha, beta, gamma, and delta subunits are assembled during T-cell development by somatic rearrangement of germline gene segments, resembling B-cell Ig genes in their mechanisms of diversity generation and activation of expression. Alpha/beta heterodimers are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented by MHC gene products. T-cells expressing gamma/delta heterodimers directly recognize proteins and non-proteinacious phospho-ligands. T-cell receptors are non-covalently associated with CD3, forming the TCR-CD3 complex. TCRs activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. (from OMIM and NCI)

T-Cell Receptor

Major Histocompatibility Complex Receptor

T-Cell Receptor

MHC Receptor

TCR

T-Cell Receptor

T-Cell_Receptor

T-Cell Receptor

Thesaurus:C17065

T-Cell Receptor

Immunologic Factor

Receptor

Amino Acid, Peptide, or Protein

C0034790

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21176