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Preferred Name

Purine Nucleoside Phosphorylase Inhibitor
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2151
CHEBI_ID

CHEBI:63090
code

C2151
DEFINITION

Any substance that inhibits purine nucleoside phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Inhibition of purine nucleoside phosphorylase results in accumulation of dGTP and the subsequent failure of DNA synthesis, with its greatest effect in T-cells.
FULL_SYN

Purine Nucleoside Phosphorylase Inhibitor
label

Purine Nucleoside Phosphorylase Inhibitor
Legacy Concept Name

Purine_Nucleoside_Phosphorylase_Inhibitor
Preferred_Name

Purine Nucleoside Phosphorylase Inhibitor
prefixIRI

Thesaurus:C2151
prefLabel

Purine Nucleoside Phosphorylase Inhibitor
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C1514609
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471
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