loading...| Preferred Name |
Poly (ADP-Ribose) Polymerase Inhibitor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62554 |
| ALT_DEFINITION |
A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. It may cause cancer cells to die. It is a type of targeted therapy. |
| CHEBI_ID |
CHEBI:62913 |
| code |
C62554 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 |
| Contributing_Source |
CTRP GDC |
| DEFINITION |
Any substance that inhibits Poly (ADP-Ribose) polymerase, an enzyme involved in detecting DNA single strand breaks and the initiation of DNA repair. Inhibition of Poly (ADP-Ribose) polymerase has direct cytotoxic effects by inhibiting DNA repair and causing cell death. |
| Display_Name |
PARP Inhibitor |
| FULL_SYN |
poly (ADP-ribose) polymerase inhibitor PARP Inhibitor Poly (ADP-Ribose) Polymerase Inhibitor Poly(ADP-Ribose) Polymerase Inhibitor PARP inhibitor |
| Is_Value_For_GDC_Property | |
| label |
Poly (ADP-Ribose) Polymerase Inhibitor |
| Legacy Concept Name |
Poly_ADP-Ribose_Polymerase_Inhibitor |
| Maps_To |
PARP inhibitor |
| Preferred_Name |
Poly (ADP-Ribose) Polymerase Inhibitor |
| prefixIRI |
Thesaurus:C62554 |
| prefLabel |
Poly (ADP-Ribose) Polymerase Inhibitor |
| Semantic_Type |
Chemical Viewed Functionally |
| UMLS_CUI |
C1882413 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||