loading...| Preferred Name |
SGLT2 Inhibitor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98083 |
| ALT_DEFINITION |
SGLT2 inhibitors inhibit the sodium glucose cotransporter 2 in the kidney, and selected agents in this class have demonstrated benefit in HF, CKD, ASCVD, and diabetes. |
| code |
C98083 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 |
| Contributing_Source |
ACC/AHA CTRP |
| DEFINITION |
Any inhibitor of the sodium-glucose co-transporter subtype 2 (SGLT2) with antihyperglycemic activity. By binding to and blocking SGLT2, these inhibitors suppress reabsorption of glucose in the proximal tubule within the kidneys and thereby enhancing urinary excretion of glucose. This eventually normalizes blood glucose levels. SGLT2, a transport system exclusively expressed in the proximal renal tubules, mediates about 90% of renal glucose reabsorption from tubular fluid. |
| Display_Name |
SGLT2 Inhibitor |
| FULL_SYN |
SGLT2 Inhibitor SGLT2 inhibitor SLC5A2 Inhibitor |
| Has_ACC-AHA_SARS2_Authorized_Value |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998 |
| Has_Target | |
| label |
SGLT2 Inhibitor |
| Preferred_Name |
SGLT2 Inhibitor |
| prefixIRI |
Thesaurus:C98083 |
| prefLabel |
SGLT2 Inhibitor |
| Semantic_Type |
Chemical Viewed Functionally |
| UMLS_CUI |
C3273807 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||