Preferred Name

Proheparin-Binding EGF-Like Growth Factor

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118380

code

C118380

DEFINITION

Proheparin-binding EGF-like growth factor (208 aa, ~23 kDa) is encoded by the human HBEGF gene. This protein plays a role in both heart valve formation and mitogenesis for fibroblasts and smooth muscle cells.

DesignNote

The active form of the growth factor, called heparin-binding EGF-like growth factor, is produced by two proteolytic cleavage events that remove 62 N-terminal amino acids and 60 amino acids from the C-terminus of proheparin-binding EGF-like growth factor. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt)

FULL_SYN

Proheparin-Binding EGF-Like Growth Factor

Pro-HB-EGF

label

Proheparin-Binding EGF-Like Growth Factor

OMIM_Number

126150

Preferred_Name

Proheparin-Binding EGF-Like Growth Factor

prefixIRI

Thesaurus:C118380

prefLabel

Proheparin-Binding EGF-Like Growth Factor

Semantic_Type

Amino Acid, Peptide, or Protein

Swiss_Prot

Q99075

UMLS_CUI

C3888283

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118379

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http://purl.obolibrary.org/obo/PR_000008459 Protein Ontology / 蛋白质本体 LOOM