| Preferred Name |
Transforming Growth Factor beta
|
| Synonyms |
Platelet Transforming Growth Factor
|
| Definitions |
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
|
| ID |
http://purl.bioontology.org/ontology/MESH/D016212
|
| altLabel |
Platelet Transforming Growth Factor Bone-Derived Transforming Growth Factor TGFbeta Factor, Milk Growth Milk Growth Factor Bone Derived Transforming Growth Factor TGF-beta Growth Factor, Milk
|
| AQL |
AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR
|
| cui |
C0040690
|
| DC |
1
|
| definition |
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
|
| DX |
19910101
|
| HN |
91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627
|
| Inverse of RB |
0
|
| Machine permutation |
91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C404602 http://purl.bioontology.org/ontology/MESH/C090409 http://purl.bioontology.org/ontology/MESH/C102095 http://purl.bioontology.org/ontology/MESH/C105817 http://purl.bioontology.org/ontology/MESH/C406030 http://purl.bioontology.org/ontology/MESH/C121965 http://purl.bioontology.org/ontology/MESH/C515087 http://purl.bioontology.org/ontology/MESH/C405802 http://purl.bioontology.org/ontology/MESH/C000620822 http://purl.bioontology.org/ontology/MESH/C089440 http://purl.bioontology.org/ontology/MESH/C097150 http://purl.bioontology.org/ontology/MESH/C117509 http://purl.bioontology.org/ontology/MESH/C445082 http://purl.bioontology.org/ontology/MESH/C094620 http://purl.bioontology.org/ontology/MESH/C090547 http://purl.bioontology.org/ontology/MESH/C513103 http://purl.bioontology.org/ontology/MESH/C424084 http://purl.bioontology.org/ontology/MESH/C571097 http://purl.bioontology.org/ontology/MESH/C472416 http://purl.bioontology.org/ontology/MESH/C076861 http://purl.bioontology.org/ontology/MESH/C499469 http://purl.bioontology.org/ontology/MESH/C516107 http://purl.bioontology.org/ontology/MESH/C113622 http://purl.bioontology.org/ontology/MESH/C079678
|
| MDA |
19900629
|
| MMR |
20150602
|
| MN |
D23.529.374.687 D12.776.467.942.775 D12.644.276.374.687 D12.776.467.374.687 D23.529.942.775 D12.644.276.954.775
|
| notation |
D016212
|
| OL |
use TRANSFORMING GROWTH FACTORS to search TRANSFORMING GROWTH FACTOR BETA & TGF-BETA 1989-90
|
| prefLabel |
Transforming Growth Factor beta
|
| TERMUI |
T048242 T048239 T048240 T217778 T048243 T048241
|
| TH |
NLM (1991) NLM (2001)
|
| tui |
T116 T123
|
| subClassOf |
http://purl.bioontology.org/ontology/MESH/D055411 http://purl.bioontology.org/ontology/MESH/D016207
|
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