loading...| Preferred Name |
Geranylgeranyltransferase I Inhibitor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104414 |
| code |
C104414 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC |
| DEFINITION |
A substance that inhibits protein geranylgeranyltransferase type 1 (GGTase-I), with potential antineoplastic activity. GGTase-I is involved in the posttranslational modification of a number of oncogenic GTPases, including K-Ras, N-Ras, RhoA, RhoC, Cdc42, RalA, RalB and Rac1. Inhibition of the prenylation of these oncogenic proteins inhibits both their oncogenic activity and membrane localization. This may result in cell cycle arrest and apoptosis. Protein geranylgeranylation, catayzed by GGTase-I, plays a critical role in malignant transformation and cancer cell proliferation, migration and invasion. |
| Display_Name |
Geranylgeranyltransferase I Inhibitor |
| FULL_SYN |
Geranylgeranyltransferase I Inhibitor GGTase-I Inhibitor GGTI-I |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Geranylgeranyltransferase I Inhibitor |
| Maps_To |
Geranylgeranyltransferase I Inhibitor |
| NCI_Drug_Dictionary_ID |
745403 |
| NCI_META_CUI |
CL445681 |
| PDQ_Closed_Trial_Search_ID |
745403 |
| PDQ_Open_Trial_Search_ID |
745403 |
| Preferred_Name |
Geranylgeranyltransferase I Inhibitor |
| prefixIRI |
Thesaurus:C104414 |
| prefLabel |
Geranylgeranyltransferase I Inhibitor |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||