loading...| Preferred Name |
Amcasertib |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104745 |
| CAS_Registry |
1129403-56-0 |
| code |
C104745 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
An orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity. Even though the exact target has not been fully elucidated, amcasertib targets and inhibits one or more pathways involved in cancer stem cell survival. As a result, cancer stem cell (CSC) growth as well as heterogeneous cancer cell growth is inhibited. CSCs, self-replicating cells able to differentiate into heterogeneous cancer cells, appear to be responsible for both tumor relapse and metastasis. |
| Display_Name |
Amcasertib |
| FDA_UNII_Code |
GLY8ABW25V |
| FULL_SYN |
AMCASERTIB BBI503 Amcasertib |
| Is_Value_For_GDC_Property | |
| label |
Amcasertib |
| Maps_To |
Amcasertib |
| NCI_Drug_Dictionary_ID |
746133 |
| NCI_META_CUI |
CL445816 |
| PDQ_Closed_Trial_Search_ID |
746133 |
| PDQ_Open_Trial_Search_ID |
746133 |
| Preferred_Name |
Amcasertib |
| prefixIRI |
Thesaurus:C104745 |
| prefLabel |
Amcasertib |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||