loading...| Preferred Name |
UAE Inhibitor TAK-243 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113788 |
| CAS_Registry |
1450833-55-2 |
| code |
C113788 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
A small molecule inhibitor of ubiquitin-activating enzyme (UAE), with potential antineoplastic activity. UAE inhibitor TAK-243 binds to and inhibits UAE, which prevents both protein ubiquitination and subsequent protein degradation by the proteasome. This results in an excess of proteins in the cells and may lead to endoplasmic reticulum (ER) stress-mediated apoptosis. This inhibits tumor cell proliferation and survival. UAE, also called ubiquitin E1 enzyme (UBA1; E1), is more active in cancer cells than in normal, healthy cells. |
| Display_Name |
UAE Inhibitor TAK-243 |
| FDA_UNII_Code |
V9GGV0YCDI |
| FULL_SYN |
UAE Inhibitor TAK-243 MLN7243 TAK-243 AOB87172 |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
UAE Inhibitor TAK-243 |
| Maps_To |
UAE Inhibitor TAK-243 |
| NCI_Drug_Dictionary_ID |
757275 |
| NCI_META_CUI |
CL471769 |
| PDQ_Closed_Trial_Search_ID |
757275 |
| PDQ_Open_Trial_Search_ID |
757275 |
| Preferred_Name |
UAE Inhibitor TAK-243 |
| prefixIRI |
Thesaurus:C113788 |
| prefLabel |
UAE Inhibitor TAK-243 |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||