loading...| Preferred Name |
Telotristat Ethyl |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150126 |
| CAS_Registry |
1033805-22-9 |
| code |
C150126 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
The ethyl ester form of telotristat, a tryptophan hydroxylase (TPH) inhibitor, with potential anti-serotonergic activity. Upon administration, telotristat binds to and inhibits the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells. |
| Display_Name |
Telotristat Ethyl |
| FDA_UNII_Code |
8G388563M7 |
| FULL_SYN |
LX1606 LX 1606 LX-1032 LX1032 LX 1032 Telotristat Ethyl LX-1606 TELOTRISTAT ETHYL |
| label |
Telotristat Ethyl |
| NCI_Drug_Dictionary_ID |
804557 |
| PDQ_Closed_Trial_Search_ID |
804557 |
| PDQ_Open_Trial_Search_ID |
804557 |
| Preferred_Name |
Telotristat Ethyl |
| prefixIRI |
Thesaurus:C150126 |
| prefLabel |
Telotristat Ethyl |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C3853880 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/DRON_00780948 | The Drug Ontology / 药物本体 | LOOM | |
| http://purl.bioontology.org/ontology/MESH/C000621725 | Medical Subject Headings / 医学主题词表 | LOOM |