loading...| Preferred Name |
Telaglenastat Hydrochloride |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150413 |
| CAS_Registry |
1874231-60-3 |
| code |
C150413 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
The hydrochloride salt form of CB-839, an orally bioavailable inhibitor of glutaminase, with potential antineoplastic and immunostimulating activities. Upon oral administration, CB-839 selectively and reversibly binds to and inhibits human glutaminase, an enzyme that is essential for the conversion of the amino acid glutamine into glutamate. Blocking glutamine metabolism inhibits proliferation in rapidly growing tumor cells and leads to an induction of cell death. Unlike normal healthy cells, glutamine-dependent tumors heavily rely on the intracellular conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. In addition, CB-839 causes accumulation of glutamine in tumor cells and increases glutamine concentration in the tumor microenvironment (TME) upon cell death. As glutamine is essential for T-cell generation, CB-839 may also enhance T-cell proliferation and activation in the TME, which may lead to further killing of tumor cells. |
| Display_Name |
Telaglenastat Hydrochloride |
| FDA_UNII_Code |
B33561JJ61 |
| FULL_SYN |
2-Pyridineacetamide, N-(5-(4-(6-((2-(3-(trifluoromethoxy)phenyl)acetyl)amino)-3-pyridazinyl)butyl)-1,3,4-thiadiazol-2-yl)-, Hydrochloride (1:1) Glutaminase Inhibitor CB-839 Hydrochloride TELAGLENASTAT HYDROCHLORIDE CB-839 HCl Telaglenastat Hydrochloride |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Telaglenastat Hydrochloride |
| Maps_To |
Glutaminase Inhibitor CB-839 Hydrochloride Telaglenastat Hydrochloride |
| NCI_Drug_Dictionary_ID |
801359 |
| NCI_META_CUI |
CL552142 |
| PDQ_Closed_Trial_Search_ID |
801359 |
| PDQ_Open_Trial_Search_ID |
801359 |
| Preferred_Name |
Telaglenastat Hydrochloride |
| prefixIRI |
Thesaurus:C150413 |
| prefLabel |
Telaglenastat Hydrochloride |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||