loading...| Preferred Name |
Sibutramine Hydrochloride |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47718 |
| CAS_Registry |
125494-59-9 |
| Chemical_Formula |
C17H26ClN.HCl.H2O |
| code |
C47718 |
| Concept_In_Subset | |
| Contributing_Source |
FDA |
| DEFINITION |
The hydrochloride salt form of sibutramine, a phenethylamine derivative with appetite depressant property. Sibutramine hydrochloride metabolites M1 and M2 competitively inhibit the reuptake of norepinephrine, serotonin, and to a lesser degree dopamine by pre-synaptic nerve terminals, thereby promoting a sense of satiety, leading to a decrease in calorie intake, and possibly an increase in resting metabolic rate. This agent does not exhibit anticholinergic or antihistaminic effects. |
| FDA_UNII_Code |
OGM0YHD1WF |
| FULL_SYN |
BTS 54524 Sibutramine Hydrochloride SIBUTRAMINE HYDROCHLORIDE Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)-, Hydrochloride Meridia HSDB 7209 |
| Has_Free_Acid_Or_Base_Form | |
| label |
Sibutramine Hydrochloride |
| Legacy Concept Name |
Sibutramine_Hydrochloride |
| Preferred_Name |
Sibutramine Hydrochloride |
| prefixIRI |
Thesaurus:C47718 |
| prefLabel |
Sibutramine Hydrochloride |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C0142278 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||