loading...| Preferred Name |
CYP11A1 Inhibitor ODM-209 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172052 |
| code |
C172052 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 |
| Contributing_Source |
GDC |
| DEFINITION |
An orally bioavailable inhibitor of the enzyme cytochrome 450 side-chain cleavage (scc)(CYP11A1), with potential antineoplastic activity. Upon oral administration, CYP11A1 inhibitor ODM-209 targets, binds to and inhibits the activity of CYP11A1. This prevents the synthesis of all steroid hormones and their precursors. This may inhibit the proliferation of hormone-positive tumor cells. CYP11A1, a mitochondrial enzyme, catalyzes the conversion of cholesterol to pregnenolone (Preg), which is the first rate-limiting step in steroid hormone biosynthesis. |
| FULL_SYN |
CYP11A1 Inhibitor ODM-209 ODM-209 ODM209 ODM 209 |
| Is_Value_For_GDC_Property | |
| label |
CYP11A1 Inhibitor ODM-209 |
| Maps_To |
CYP11A1 Inhibitor ODM-209 |
| NCI_Drug_Dictionary_ID |
801473 |
| NCI_META_CUI |
CL1406195 |
| PDQ_Closed_Trial_Search_ID |
801473 |
| PDQ_Open_Trial_Search_ID |
801473 |
| Preferred_Name |
CYP11A1 Inhibitor ODM-209 |
| prefixIRI |
Thesaurus:C172052 |
| prefLabel |
CYP11A1 Inhibitor ODM-209 |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||