loading...| Preferred Name |
Quinolonyl-oxazolidinone Antibiotic DNV3837 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173413 |
| CAS_Registry |
790704-50-6 |
| code |
C173413 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
A prodrug of DNV3681, a small molecule quinolonyl-oxazolidinone antibiotic with activity against Gram-positive bacteria, including Clostridioides difficile. Upon intravenous administration, DNV3837 crosses the gastrointestinal barrier to reach the C. difficile infection site. The active drug DNV3681 may affect four bacterial targets including DNA-gyrase, topoisomerase IV, protein synthesis and aminoacyl-t-RNA synthetases, which leads to bacterial cell death. DNV3681 does not have antibacterial activity against aerobic and anaerobic Gram-negative bacteria, sparing intestinal Bacteroides spp. that provide colonization resistance in the digestive tract. |
| Display_Name |
Quinolonyl-oxazolidinone Antibiotic DNV3837 |
| FDA_UNII_Code |
1221R21ZRQ |
| FULL_SYN |
Quinolonyl-oxazolidinone Antibiotic DNV3837 DNV3837 MCB3837 MCB 3837 DNV 3837 MCB-3837 DNV-3837 |
| label |
Quinolonyl-oxazolidinone Antibiotic DNV3837 |
| NCI_Drug_Dictionary_ID |
802214 |
| NCI_META_CUI |
CL1407230 |
| PDQ_Closed_Trial_Search_ID |
802214 |
| PDQ_Open_Trial_Search_ID |
802214 |
| Preferred_Name |
Quinolonyl-oxazolidinone Antibiotic DNV3837 |
| prefixIRI |
Thesaurus:C173413 |
| prefLabel |
Quinolonyl-oxazolidinone Antibiotic DNV3837 |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||