loading...| Preferred Name |
NAMPT Inhibitor STF-118804 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177896 |
| code |
C177896 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 |
| Contributing_Source |
GDC |
| DEFINITION |
A small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD)-synthesizing enzyme nicotinamide phosphoribosyltransferase (NAMPT; NAMPRTase), with potential antineoplastic activity. Upon administration, NAMPT inhibitor STF-118804 binds to and inhibits the activity of NAMPT. This depletes cellular NAD and inhibits NAD-dependent enzymes, both of which are needed for rapid cell proliferation, which may result in cell death in NAMPT-overexpressing tumor cells. NAMPT, an enzyme that is responsible for maintaining the intracellular NAD pool, plays a key role in the regulation of cellular metabolism and has cytokine-like activities. NAMPT is overexpressed in a variety of cancers and metabolic disorders; tumor cells rely on NAMPT activity for their NAD supply. |
| FULL_SYN |
STF118804 NAMPT Inhibitor STF-118804 STF 118804 STF-118804 |
| Has_Target | |
| label |
NAMPT Inhibitor STF-118804 |
| NCI_META_CUI |
CL1647485 |
| Preferred_Name |
NAMPT Inhibitor STF-118804 |
| prefixIRI |
Thesaurus:C177896 |
| prefLabel |
NAMPT Inhibitor STF-118804 |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||