loading...| Preferred Name |
Multi-kinase Inhbitor AIV001 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178338 |
| code |
C178338 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 |
| Contributing_Source |
GDC |
| DEFINITION |
A prolonged-release multi-kinase inhibitor, with potential anti-angiogenic, anti-fibrotic and antineoplastic activities. Upon intradermal or intratumoral administration, AIV001 targets and binds to several kinases, including vascular endothelial growth factor receptor (VEGFR), and inhibits multiple pathways involved in neovascularization, fibrosis, abnormal cell proliferation and inflammation. This may reduce dermal neovascularization and fibroplasia during wound healing and scarring, reduce inflammation and fibrosis associated with certain skin conditions, and may reduce neovascularization and cell proliferation associated with certain types of cancers. |
| FULL_SYN |
AIV 001 Multi-kinase Inhbitor AIV001 AIV001 AIV-001 |
| Has_Target | |
| label |
Multi-kinase Inhbitor AIV001 |
| NCI_Drug_Dictionary_ID |
804133 |
| NCI_META_CUI |
CL1647828 |
| PDQ_Closed_Trial_Search_ID |
804133 |
| PDQ_Open_Trial_Search_ID |
804133 |
| Preferred_Name |
Multi-kinase Inhbitor AIV001 |
| prefixIRI |
Thesaurus:C178338 |
| prefLabel |
Multi-kinase Inhbitor AIV001 |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||