loading...| Preferred Name |
ACSS2 Inhibitor MTB-9655 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C181770 |
| code |
C181770 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 |
| Contributing_Source |
GDC |
| DEFINITION |
An orally bioavailable small molecule inhibitor of the enzyme human acetyl coenzyme A synthetase short chain family member 2 (ACSS2; acetyl CoA synthetase 2), with potential antineoplastic activity. Upon oral administration, the ACSS2 inhibitor MTB-9655 selectively targets, binds to and inhibits the activity of ACSS2. This prevents acetate metabolism to acetyl-CoA which may lead to an inhibition of tumor cell proliferation. ACSS2, an enzyme that converts acetate to acetyl-CoA, is upregulated in cancer cells in response to low nutrient availability and hypoxia. Stressed cancer cells utilize acetate as an alternative nutrient source for cell growth. |
| FULL_SYN |
MTB 9655 MTB-9655 MTB9655 ACSS2 Inhibitor MTB-9655 Acetyl-CoA Synthetase 2 Inhibitor MTB-9655 |
| label |
ACSS2 Inhibitor MTB-9655 |
| NCI_Drug_Dictionary_ID |
806021 |
| NCI_META_CUI |
CL1664644 |
| Preferred_Name |
ACSS2 Inhibitor MTB-9655 |
| prefixIRI |
Thesaurus:C181770 |
| prefLabel |
ACSS2 Inhibitor MTB-9655 |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||