HSD-1 Inhibitor SPI-62

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187308

C187308

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

CTRP

GDC

An orally bioavailable selective inhibitor of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1; 11bHSD1; HSD11B1; HSD1; HSD-1), with potential protective activity for disorders of corticosteroid excess. Upon oral administration, HSD-1 inhibitor SPI-62 selectively binds to and inhibits the activity of HSD-1. This prevents the conversion of cortisone to the active hormone cortisol and thereby preventing the activation of the glucocorticoid receptors (GRs). By blocking cortisol production in metabolic tissues, SPI-62 may inhibit the adverse metabolic effects that are caused by exogenous administration of glucocorticoids or in disorders in which cortisol is secreted in excess. HSD-1 is highly expressed in metabolic tissues, such as liver, skeletal muscle, and adipose tissue. It plays a crucial role in regulating the production of cortisol to activate the GRs.

HSD-1 Inhibitor SPI-62

11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor SPI-62

SPI62

HSD-1 Inhibitor SPI-62

SPI 62

SPI-62

PFKFB3 Inhibitor PFK-158

HSD-1 Inhibitor SPI-62

809507

CL1792255

HSD-1 Inhibitor SPI-62

Thesaurus:C187308

HSD-1 Inhibitor SPI-62

Pharmacologic Substance

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471