Signal Recognition Particle Ribonucleoprotein Complex

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C200610

C200610

A ribonucleoprotein complex that targets certain nascent proteins to the endoplasmic reticulum (ER) during translation. In eukaryotes, the signal recognition particle complex (SRP) recognizes the N-terminal hydrophobic signal peptide sequence on nascent peptide chains as they emerge from the ribosome. Next, the SRP slows translation and docks the complex of the ribosome and nascent peptide with the SRP receptor and translocon channel that are co-located in the membrane of the ER. Then, the SRP is released and translation elongation resumes.

Autoantibodies targeting the signal recognition particle are associated with polymyositis.

In humans, the signal recognition particle is comprised of 6 proteins (SRP-9, -14, -19, -54, -68, and -72) and three 7SL RNA components (RN7SL1, RN7SL2 and RN7SL3).

Signal Recognition Particle Complex

SRP

SRP Complex

SRP Ribonucleoprotein Complex

Signal Recognition Particle

Signal Recognition Particle Ribonucleoprotein Complex

Signal Recognition Particle Ribonucleoprotein Complex

Signal Recognition Particle Ribonucleoprotein Complex

Thesaurus:C200610

Signal Recognition Particle Ribonucleoprotein Complex

Enzyme

Amino Acid, Peptide, or Protein

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21176