Type VII Collagen

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C200656

C200656

Type VII collagen is a homotrimeric helical complex of the collagen alpha-1(VII) chain protein (COL7A1). This collagen is the major component of anchoring fibrils, which are specialized extracellular attachment complexes that form at the epithelium/mesenchyme interface in certain tissues. Following secretion of the triple-helical complex, two type VII collagen molecules align into an anti-parallel dimer, the carboxy-terminal non-collagenous domains (NC2) of both type VII collagen molecules are proteolytically removed and the anti-parallel dimer is stabilized by intermolecular disulfide bond formation. A large number of the stabilized anti-parallel dimers aggregate laterally to form anchoring fibrils.

Type VII Collagen

Collagen VII

Collagen Type VII

Type VII Collagen

Type VII Collagen

Thesaurus:C200656

Type VII Collagen

19945621

Amino Acid, Peptide, or Protein

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21176

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16447