loading...| Preferred Name |
Gamma-Glutamylcysteine Synthetase Inhibitor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2130 |
| code |
C2130 |
| DEFINITION |
Any substance that inhibits glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme that catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine, the rate-limiting step in the biosynthesis of glutathione. Since glutathione is critical in protecting cells against oxidative stress, its depletion results in free radical-induced apoptosis. |
| FULL_SYN |
GCS Inhibitors Gamma-Glutamylcysteine Synthetase Inhibitor Glutathione Synthesis Inhibitors Glutamate-cysteine Ligase Inhibitor |
| label |
Gamma-Glutamylcysteine Synthetase Inhibitor |
| Legacy Concept Name |
Gamma-Glutamylcysteine_Synthetase_Inhibitor |
| Preferred_Name |
Gamma-Glutamylcysteine Synthetase Inhibitor |
| prefixIRI |
Thesaurus:C2130 |
| prefLabel |
Gamma-Glutamylcysteine Synthetase Inhibitor |
| Semantic_Type |
Chemical Viewed Functionally |
| UMLS_CUI |
C1517431 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||