Histone-Lysine N-Methyltransferase SETDB1

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29940

C29940

Histone-lysine N-methyltransferase SETDB1 (1291 aa, ~143 kDa) is encoded by the human SETDB1 gene. This protein is involved in histone methylation.

Histone H3-K9 Methyltransferase 4 methylates histone H3 Lys-9 in epigenetic transcriptional repression that recruits HP1 proteins to methylated histones. SETDB1 contains an MBD domain, a pre-SET, a SET, and a post-SET domain, and 2 Tudor domains; pre-SET, SET and post-SET are required for methyltransferase activity. Isoform 2 lacks all methyltransferase domains. The conserved SET domain is implicated in transcriptional modulation of active or repressed chromatin through remodeling. Targeted to histone by TRIM28/TIF1B, SETDB1 contributes to euchromatic gene silencing by KRAB zinc-finger proteins and may interact with ERG.

Lysine N-Methyltransferase 1E

Histone-Lysine N-Methyltransferase SETDB1

ERG-Associated Protein with Set Domain

ESET

EC 2.1.1.43

H3-K9-HMTase 4

Histone H3-K9 Methyltransferase 4

Histone-Lysine N-Methyltransferase H3 Lysine-9 Specific 4

SET Domain Bifurcated 1

SETDB1

Histone-Lysine N-Methyltransferase SETDB1

Histone-H3-K9_Methyltransferase-4

604396

Histone-Lysine N-Methyltransferase SETDB1

Thesaurus:C29940

Histone-Lysine N-Methyltransferase SETDB1

Enzyme

Amino Acid, Peptide, or Protein

Q15047

C1122259

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16849