loading...| Preferred Name |
Interferon Alpha Receptor Complex |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37274 |
| code |
C37274 |
| Concept_In_Subset | |
| Contributing_Source |
CTRP |
| DEFINITION |
Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI) |
| Display_Name |
Interferon Alpha Receptor Complex |
| FULL_SYN |
Interferon-Alpha-Beta Receptor Interferon Beta Receptor Interferon Alpha Receptor Interferon Alpha Receptor Complex |
| label |
Interferon Alpha Receptor Complex |
| Legacy Concept Name |
Interferon_Alpha_Receptor_Complex |
| Preferred_Name |
Interferon Alpha Receptor Complex |
| prefixIRI |
Thesaurus:C37274 |
| prefLabel |
Interferon Alpha Receptor Complex |
| Semantic_Type |
Receptor Amino Acid, Peptide, or Protein |
| UMLS_CUI |
C0254653 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||