loading...| Preferred Name |
Interferon Gamma Receptor Complex |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37279 |
| code |
C37279 |
| DEFINITION |
Expressed in monocytes, lymphocytes, and placenta, human Interferon Gamma Receptor Complex (Type II Cytokine Family Receptor) is a Ser/Thr phosphorylated type I membrane protein heteromeric receptor for IFN-gamma, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. In mediating innate immune responses to viral infection, binding of IFN-gamma activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain while the integral accessory factor IFNGR2 is required for signal transduction and may interact with GAF, JAK1, and/or JAK2. (NCI) |
| DesignNote |
Protein_Plays_Role_In_Biological_Process: Macrophage Activation |
| FULL_SYN |
IFN-Gamma Receptor Interferon Gamma Receptor Complex |
| label |
Interferon Gamma Receptor Complex |
| Legacy Concept Name |
Interferon_Gamma_Receptor_Complex |
| Preferred_Name |
Interferon Gamma Receptor Complex |
| prefixIRI |
Thesaurus:C37279 |
| prefLabel |
Interferon Gamma Receptor Complex |
| Semantic_Type |
Receptor Amino Acid, Peptide, or Protein |
| UMLS_CUI |
C1334197 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||