loading...| Preferred Name |
Multikinase Inhibitor AT9283 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66947 |
| ALT_DEFINITION |
A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. AT9283 is a type of serine/threonine protein kinase inhibitor. |
| CAS_Registry |
896466-04-9 |
| code |
C66947 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
A small synthetic molecule and aurora kinase (AK) inhibitor with potential antineoplastic activity. AT9283 selectively binds to and inhibits AKs A and B, which are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Inhibition of these kinases results in an inhibition of cellular division and proliferation in tumor cells that overexpress AKs. |
| Display_Name |
Multikinase Inhibitor AT9283 |
| FDA_UNII_Code |
XAV9KYN9WL |
| FULL_SYN |
AT9283 Multikinase Inhibitor AT9283 AT-9283 Aurora kinase inhibitor AT9283 |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Multikinase Inhibitor AT9283 |
| Legacy Concept Name |
AT9283 |
| Maps_To |
Multikinase Inhibitor AT9283 |
| NCI_Drug_Dictionary_ID |
534287 |
| PDQ_Closed_Trial_Search_ID |
534287 |
| PDQ_Open_Trial_Search_ID |
534287 |
| Preferred_Name |
Multikinase Inhibitor AT9283 |
| prefixIRI |
Thesaurus:C66947 |
| prefLabel |
Multikinase Inhibitor AT9283 |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C1879521 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||