| Preferred Name |
Human Lactoferrin Peptide hLF1-11 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67046 |
| CAS_Registry |
183623-03-2 |
| code |
C67046 |
| Concept_In_Subset | |
| Contributing_Source |
FDA |
| DEFINITION |
A synthetic peptide corresponding to the first 11 N-terminal amino acids of human lactoferrin (hLF1-11) with potential antimicrobial activity. Human lactoferrin, a 692 amino acid glycoprotein belonging to the transferrin family of metal-binding proteins, can be found in milk and other secretory fluids as well as in polymorphonuclear cells and leukocytes. Human lactoferrin plays a role in the innate defense of mucosal surfaces and neutrophils. Although the exact mechanism through which this peptide exerts its effect has yet to be fully elucidated, hLF1-11 may seize iron, thereby limiting the availability of free iron for microorganisms in the body. hLF1-11 appears to be effective against a variety of bacteria and fungi, including the multidrug-resistant Acinetobacter baumannii, multidrug-resistant Staphylococcus aureus, and fluconazole-resistant Candida albicans strains. |
| FDA_UNII_Code |
72YOI2Q5AK |
| FULL_SYN |
HLF(1-11) Human Lactoferrin Peptide hLF1-11 hLF(1-11) |
| label |
Human Lactoferrin Peptide hLF1-11 |
| Legacy Concept Name |
Human_Lactoferrin_1-11_Peptide |
| NCI_Drug_Dictionary_ID |
537368 |
| PDQ_Closed_Trial_Search_ID |
537368 |
| PDQ_Open_Trial_Search_ID |
537368 |
| Preferred_Name |
Human Lactoferrin Peptide hLF1-11 |
| prefixIRI |
Thesaurus:C67046 |
| prefLabel |
Human Lactoferrin Peptide hLF1-11 |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C1144139 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||