Preferred Name

Human Lactoferrin Peptide hLF1-11

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67046

CAS_Registry

183623-03-2

code

C67046

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

Contributing_Source

FDA

DEFINITION

A synthetic peptide corresponding to the first 11 N-terminal amino acids of human lactoferrin (hLF1-11) with potential antimicrobial activity. Human lactoferrin, a 692 amino acid glycoprotein belonging to the transferrin family of metal-binding proteins, can be found in milk and other secretory fluids as well as in polymorphonuclear cells and leukocytes. Human lactoferrin plays a role in the innate defense of mucosal surfaces and neutrophils. Although the exact mechanism through which this peptide exerts its effect has yet to be fully elucidated, hLF1-11 may seize iron, thereby limiting the availability of free iron for microorganisms in the body. hLF1-11 appears to be effective against a variety of bacteria and fungi, including the multidrug-resistant Acinetobacter baumannii, multidrug-resistant Staphylococcus aureus, and fluconazole-resistant Candida albicans strains.

FDA_UNII_Code

72YOI2Q5AK

FULL_SYN

HLF(1-11)

Human Lactoferrin Peptide hLF1-11

hLF(1-11)

label

Human Lactoferrin Peptide hLF1-11

Legacy Concept Name

Human_Lactoferrin_1-11_Peptide

NCI_Drug_Dictionary_ID

537368

PDQ_Closed_Trial_Search_ID

537368

PDQ_Open_Trial_Search_ID

537368

Preferred_Name

Human Lactoferrin Peptide hLF1-11

prefixIRI

Thesaurus:C67046

prefLabel

Human Lactoferrin Peptide hLF1-11

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1144139

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C254

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