loading...| Preferred Name |
Nanafrocin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72594 |
| CAS_Registry |
52934-83-5 |
| CHEBI_ID |
CHEBI:48202 |
| Chemical_Formula |
C16H14O6 |
| code |
C72594 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 |
| Contributing_Source |
GDC FDA |
| DEFINITION |
A quinone antibiotic isolated from Streptomyces rosa var. notoensis with activity against gram-positive bacteria, mycoplasmas and fungi. Within an organism, nanaomycin A is first reduced by flavin or NADH dehydrogenase then rapidly autooxidized leading to the production of singlet molecular oxygen (O2-). The increase in intracellular O2- results in inhibition of DNA, RNA and cell-wall peptidoglycan synthesis. Further, nanaomycin A may have antineoplastic properties resulting from a reduction in DNA methylation by inhibiting DNA methyltransferase 3B (DNMT3B) and reactivating the tumor suppressor gene RASSF1A. |
| FDA_UNII_Code |
8XBV72641V |
| FULL_SYN |
NANAFROCIN Nanaomycin A (1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic Acid Nanafrocin OS 3966-A |
| Is_Value_For_GDC_Property | |
| label |
Nanafrocin |
| Legacy Concept Name |
Nanafrocin |
| Maps_To |
Nanafrocin |
| Preferred_Name |
Nanafrocin |
| prefixIRI |
Thesaurus:C72594 |
| prefLabel |
Nanafrocin |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C0068391 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||